Use of an Oxygen Controlled Workstation with High-Efficiency HEPA-Filtration System in Drug Toxicity Studies Incompatible with Antibiotic Media Supplementation

ABSTRACT
In drugs toxicity testing, the quality of the atmosphere in which cell handling is carried out is of heightened importance due to the inability to supplement culture media with antibiotics. Further to this, many researchers wish to use low oxygen environments to ensure their model in-vitro systems are as physiologically relevant to the in-vivo system as possible.

This document describes the use of a Whitley H35 HEPA Hypoxystation to provide a HEPA filtered, environmentally defined, work and incubation space for drug toxicity testing in a cardiac spheroid model, whilst also allowing pre-programmed oxygen profiles to simulate the in-vivo system in health and disease.

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