Investigating Disease Mechanisms: Advancements in Metabolic Analysis
Join us for a free webinar on "Investigating Disease Mechanisms: Advancements in Metabolic Analysis" featuring leading specialists who are using the state-of-the-art Seahorse Analyser in a physiologically relevant atmosphere to unlock the mysteries of metabolic processes underlying diseases.
Discover the latest advancements in metabolic analysis, gain insights into cutting-edge research, and learn how this powerful tool is transforming our understanding of disease mechanisms. Don't miss this exciting opportunity to learn from experts in the field and stay up-to-date on the latest developments in metabolic analysis.
Register now and get ready to delve into the fascinating world of metabolic research!
Dr Scott Allen
Investigating mechanisms of hypoxic induced metabolic dysfunction in neurodegenerative disease models.
Dr Allen has 25 years of academic and pharmaceutical research expertise and has extensive experience of using novel approaches to uncover mechanisms of dysfunction in CNS health and disease. The main research focus of his group is identifying the role of dysfunctional energy generation in neurodegenerative conditions, with a particular interest in amyotrophic lateral sclerosis (ALS). Dr Allen was the first in the field to use an XF bioanalyser and an OmniLog™ phenotypic metabolic screening approach to identify novel pathways of metabolic dysfunction in human models of ALS. His lab's primary aim is to develop therapeutic nutritional strategies by combining mechanistic metabolic profiling in cell models alongside uncovering metabolic markers in patient biofluids.
Dr Johann Matschke
Identification of metabolic mechanisms driving cancer cell radiation resistance and associated therapeutic opportunities.
Cancer bioenergetics fuels processes necessary to maintain viability and growth under adverse microenvironmental stress conditions to ensure survival upon radiotherapy. Thus,
identification of metabolic bottlenecks induced by adaptation to acute or chronic cycling hypoxia represent opportunities for therapeutic intervention.Among such energy-demanding
cellular stress responses are the repair of radiation-induced DNA double-strand breaks (DSBs) and the balance of reduction and energy equivalents. However, an exact mechanism and a link between cancer metabolism, DNA damage response and survival remains elusive. We
hypothesize, that radiation-induced context-specific metabolic vulnerabilities represent a viable therapeutic strategy for radio sensitization.
Dr Jonathon Gilthorpe
Department for Integrative Medical Biology, Umeå University, Sweden
Combining an oxygen regulated environment and Seahorse to understand the intersection between cell metabolism and disease pathogenesis.
Dr. Jonathan D. Gilthorpe is Associate Professor in Experimental Neuroscience at the Department of Integrative Medical Biology (IMB), Umeå University, Sweden. Jonathan’s research involves the use of cell models to understand disease pathogenesis, with a particular focus on the motor neuron disease ALS, where oxygen dependent processes intersect with metabolic dysfunction. Combining patient-derived cell models with the power of Seahorse metabolic flux assays and a regulated oxygen environment is an important approach, which Jonathan will talk about in his presentation.
Event hosted and organised by Don Whitley Scientific Limited.